Master of Science (M.Sc.) in Chemical and Biological Engineering
Program tanımlarıProgram Description
Chemical & Biological Engineering is a discipline that integrates chemistry and biology at the molecular level and uses this broad foundation along with engineering fundamentals to study the synthesis of new processes and products. Our graduate program in Chemical and Biological Engineering is an interdisciplinary program that combines chemical engineering fundamentals and systems biology to meet the research challenges of the future.
Research Areas of Interest
Drug Discovery
Tissue Engineering
Plant Biotechnology
Protein-Protein Interactions
Protein Folding
Process Dynamics, Control and Optimization
Process Systems Engineering
Catalysis
Supercritical Fluids
Synthesis of Nanostructured Materials
Fuel Cells and Sustainable Development
Computational Fluid Dynamics
Polymer Science and Engineering
Microfluidics
Biological Clock
Interaction Networks and Pathways
Faculty
Yaman Arkun
Burak Erman
Can Erkey
Ozlem Keskin
Seda Kizilel
Metin Turkay
Iskender Yilgor
Atilla Gursoy
I.Halil Kavakli
Metin Muradoglu
Curriculum Required core courses (3 credit each):
Math 503 Applied Mathematics ChBi 501 Transport Phenomena ChBi 503 Thermodynamics
Elective courses (3 credit each):
ChBi 502 Reaction Engineering ChBi 504 Advanced Thermodynamics ChBi 505 Polymer Engineering ChBi 506 Bioinformatics ChBi 507 Advanced Mass transfer ChBi 509 Fundamentals of Environmental Technologies ChBi 510 Industrial Microbiology ChBi 511 Sustainable Energy ChBi 516 Biotechnology ChBi 521/MECH 521 Advanced Fluid Dynamics ChBi 522/MECH 522 Computational Fluid Dynamics ChBi 530 Systems Biology ChBi 584 Tissue Engineering CMSE 520 Biomolecular Structure, Function and Dynamics CMSE 580 Selected Topics in Computational Sciences and Engineering ENGR 500 Applied Optimal Control INDR 501 Optimization Models and Algorithms MASE 501 Structure of Materials (1,5 credits) MASE 502 Electrical & Optical Properties of Materials (1,5 credits) MASE 504 Thermal Properties of Materials (1,5 credits) MASE 505 Mechanical Properties of Materials (1,5 credits) MASE 506 Synthesis, Characterization & Processing of Materials MASE 538 Intermolecular and Surface Forces MASE 540 Surface & Interface Properties of Materials MASE 542 Biomaterials MASE 570 Micro and Nanofabrication
Courses are selected by the students from the above list and from other courses not listed here in accordance with their areas of specialization and subject to the approval of their advisors. In addition, each student has to take a seminar course, CHBI 590 Seminar. Students also register for the thesis course.
CHBI 590
Seminar
CHBI 595
MS Thesis
Students who have TA assignments must take TEAC 500: Teaching Experience during the semesters of their assignments. Students must also take ENGL 500: Graduate Writing course.
Students from other disciplines
Students who do not have a formal degree in Chemical and Biological Engineering are encouraged to apply. Once they are admitted, their course program is designed to make up for any lack of background. These students will attend our undergraduate courses in fluid mechanics, heat and mass transfer, if they have not taken such courses earlier. With this additional course work they will be able to take the graduate required courses and obtain a strong educational background. For these students the course schedule will be tailored but a typical coarse load includes:
YEAR 1
Fall Semester
ChBi 301 Fluid Mechanics
MATH 503 Applied Math
ChBi 503 Thermodynamics
Spring Semester ChBi 302 Heat and Mass Transfer;
Graduate Electives (1 or 2)
YEAR 2 Fall Semester ChBi 501 Transport Phenomena
Graduate Electives (1 or none)
Course Descriptions
MATH 503
Applied Mathematics Review of Linear Algebra and Vector Fields: Vector Spaces, Eigenvalue Problems, Quadratic Forms, Divergence Theorem and Stokes' Theorem. Sturm-Liouville Theory and Orthogonal Polynomials, Methods of Solution of Boundary Value Problems for the Laplace Equation, Diffusion Equation and the Wave Equation. Elements of Variational Calculus.
ChBi 501
Transport Phenomena Fluids classification; transport coefficients; momentum transfer and velocity profiles; energy and mass transfer for isothermal and multicomponent systems; mass transfer with chemical reaction; applications for chemical and biological systems.
ChBi 502
Reaction Engineering Design and operation of chemical reactors. Homogeneous, heterogeneous and biochemical reactions. Ideal and non-ideal reactors. Kinetics of enzyme-catalyzed reactions. Kinetics of substrate utilization and biomass production.
ChBi 503
Thermodynamics Classical thermodynamics: enthalpy, entropy, free energies, equilibria; introduction to statistical thermodynamics to describe the properties of materials; kinetic processes; diffusion of mass, heat, energy; fundamentals of rate processes in materials, kinetics of transformations.
ChBi 504
Advanced Thermodynamics Principles of phase and chemical equilibria; computational methods for phase and chemical equilibria calculations; applications for chemical and biological systems.
ChBi 505
Polymer Engineering Polymers, their synthesis and properties. Relationships between molecular structure and properties. Rheology in polymer processing. Fabrication methods and applications.
ChBi 506
Bioinformatics The principles and computational methods to study the biological data generated by genome sequencing, gene expressions, protein profiles, and metabolic fluxes. Application of arithmetic, algebraic, graph, pattern matching, sorting and searching algorithms and statistical tools to genome analysis. Applications of Bioinformatics to metabolic engineering, drug design, and biotechnology.
ChBi 507
Advanced Mass Transfer Fundamentals of diffusion; primary mechanisms for mass transfer; mass transfer coupled with chemical reactions; membrane processes and controlled release phenomena.
ChBi 509
Fundamentals of Environmental Technologies Fundamentals of physicochemical and biological processes used for waste minimization, air pollution control, water pollution control, hazardous waste control; environmentally conscious design of chemical processes.
ChBi 510
Industrial Microbiology Key aspects of microbial physiology; exploring the versatility of microorganisms and their diverse metabolic activities and products; industrial microorganisms and the technology required for large-scale cultivation.
ChBi 511
Sustainable Energy Examination of the technologies, environmental impacts and economics of main energy sources of today and tomorrow including fossil fuels, nuclear power, biomass, geothermal energy, hydropower, wind energy, and solar energy. Comparison of different energy systems within the context of sustainability.
ChBi 516
Biotechnology Recombinant DNA, enzymes and other biomolecules. Molecular genetics. Commercial use of microorganisms. Cellular reactors; bioseparation techniques. Transgenic systems. Gene therapy. Biotechnology applications in environmental, agricultural and pharmaceutical problems.
CHBI 530
System Biology Reconstruction of metabolic network from genome information and its structural and functional analysis, computational models of biochemical reaction networks; system biology in drug discovery and proteomics, flux balance analysis; modeling of gene expression; system biology in artificial intelligence. These concepts will be supported with statistic, thermodynamic, structural biology and learning machine.
CHBI 580
Selected Topics in Chemical and Biological Engineering Topics will be announced when offered.
CHBI 584
Tissue Engineering The fundamentals of tissue engineering at the molecular and cellular level; techniques in tissue engineering; problems and solution in tissue engineering; transplantation of tissues in biomedicine using sophisticated equipments and materials; investigation of methods for the preparation of component of cell, effect of growth factors on tissues.
CMSE 520
Biomolecular Structure, Function and Dynamics Relationship between structure, function and dynamics in biomolecules. Overview of the biomolecular databases and application of computational methods to understand molecular interactions; networks. Principles of computational modeling and molecular dynamics of biological systems.
ENGR 500
Applied Optimal Control Optimization problems for dynamical systems. Pontryagin’s Maximum Principle. Optimality conditions for nonlinear dynamical systems. Linear Quadratic Optimal Control of continuous and discrete linear systems using finite and infinite time horizons. Stability and performance analysis of the properties of the optimal feedback solutions. Moving horizon optimal control of constrained systems using Model Predictive Control formulation. Applications from different disciplines and case studies.
INDR 501 Optimization Models and Algorithms Convex analysis, optimality conditions, linear programming model formulation, simplex method, duality, dual simplex method, sensitivity analysis; assignment, transportation, and transshipment problems.
MASE 501 (1,5 credits)
Structure of Materials Structure of materials; atomic structure and bonding, crystalline solids, symmetry, lattice and unit cell, determination of crystal structures; imperfections, defects in metals, vacancies, substitutional and interstitial impurities, dislocation defects in ionic solids.
MASE 502 (1,5 credits)
Electrical & Optical Properties of Materials Electrical properties of materials, band theory of solids, electrical conductivity, metals, semiconductors, and dielectrics; magnetic phenomena, ferromagnetism and diamagnetism, superconductors; optical properties of materials, refractive index, dispersion, absorption and emission of light, nonlinear optical properties, second- and third-order susceptibilities, Raman effect.
MASE 504 (1,5 credits)
Thermal Properties of Materials Thermal properties of metals, polymers, ceramics and composites in relation to their structure & morphology; change in microstructural mechanisms and macroscopic behaviour with temperature; crystallization, melting & glass transition.
MASE 505 (1,5 credits)
Mechanical Properties of Materials Mechanical properties of metals, polymers, ceramics and composites in relation to their structure & morphology; stress-strain behaviour; elastic deformation, yielding, plastic flow; viscoelasticity; strengthening mechanisms, fracture, fatigue, creep.
MASE 506
Synthesis, Characterization & Processing of Materials Experimental projects in the laboratory including topics from polymer synthesis & processing, composite materials, inorganic material/ceramic processing, metal processing, optical properties, electrical & magnetic properties, interfacial properties.
MASE 538
Intermolecular and Surface Forces Intermolecular forces which govern self-organization of biological and synthetic nanostructures. Thermodynamic aspects of strong (covalent and coulomb interactions) and weak forces (dipolar, hydrogen bonding). Self-assembling systems: micelles, bilayers, and biological membranes. Computer simulations for “hands-on” experience with nanostructures.
MASE 540
Surface & Interface Properties of Materials Fundamental physico-chemical concepts of surface and interface science; interaction forces in interfacial systems; surface thermodynamics, structure and composition, physisorption and chemisorption; fluid interfaces; colloids; amphiphilic systems; interfaces in polymeric systems & polymer composites; liquid coating processes.
MASE 542
Biomaterials Materials for biomedical applications; synthetic polymers, metals and composite materials as biomaterials; biopolymers, dendrimers, hydrogels, polyelectrolytes, drug delivery systems, implants, tissue grafts, dental materials, ophthalmic materials, surgical materials, imaging materials. Prerequisite: At least one semester of organic chemistry or consent of the instructor.
MASE 570
Micro and Nanofabrication Fabrication and characterization techniques for micro and nano electro mechanical systems, MEMS & NEMS (including: microlithography; wet & dry etching techniques; physical & chemical vapor deposition processes; electroplating; bonding; focused ion beams; top-down approaches - electron-beam lithography, SPM, soft lithography - ; bottom-up techniques based on self-assembly). Semiconductor nanotechnology. Nanotubes & nanowires. Biological systems. Molecular electronics.
ChBi 521
Advanced Fluid Dynamics Foundations of fluid mechanics introduced at an advanced level. Aspects of kinetic theory as it applies to formulation of continuum fluid dynamics. Introduction to tensor analysis and derivation of Navier Stokes equations and energy equation for compressible fluids. Boundary conditions and surface phenomena. Viscous flows, boundary layer theory, potential flows and vorticity dynamics. Introduction to turbulence and turbulent flows. Prerequisite: MATH 204,and MECH 301 or consent of the instructor.
ChBi 522
Computational Fluid Dynamics Numerical methods for elliptic, parabolic, hyperbolic and mixed type partial differential equations arising in fluid flow and heat transfer problems. Finite-difference, finite-volume and some finite-element methods. Accuracy, convergence, and stability; treatment of boundary conditions and grid generation. Review of current methods. Assignments require programming a digital computer.
ChBi 590
Seminar A series of lectures given by faculty or outside speakers. Participating students must also make presentations during the semester.
ChBi 595
M.S. Thesis Independent research towards M.S. degree.
TEAC 500
Teaching Experience Provides hands-on teaching experience to graduate students in undergraduate courses. Reinforces students' understanding of basic concepts and allows them to communicate and apply their knowledge of the subject matter.
ENGL 500
Graduate Writing This is a writing course specifically designed to improve academic writing skills as well as critical reading and thinking. The course objectives will be met through extensive reading, writing and discussion both in and out of class. Student performance will be assessed and graded by Satisfactory/Unsatisfactory.